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KMID : 0387820120190020105
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Clinical Pediatric Hematology-Oncology
2012 Volume.19 No. 2 p.105 ~ p.108
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Two Cases of Infant-onset Cutaneous Mastocytosis
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Cho Min-Jung
Jung Sung-Soo
Lee Min-Kyung
Park Jin
Hwang Pyoung-Han
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Abstract
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Mastocytosis is a rare disease in infants and children that characterized by a pathologic increase and accumulation of mast cells in one or more organs. Cutaneous mastocytosis is a typical presentation of pediatric-onset mastocytosis and often presents classical symptoms and signs related with mast cell mediator including pruritus, flushing, abdomi-nal pain and Darier’s sign. We present our experience with two rare cases of cutaneous mastocytosis, a 3-month-old boy and a 4-month-old boy. The former had a recurrent single brownish plaque with yellowish bullae in right forearm without any other symp-tom or sign. The latter had multiple brownish plaques in his trunk and extremities with intermittent diarrhea and Darier’s sign. In each, a punch biopsy confirmed the diagnosis of solitary mastocytoma and urticaria pigmentosa. After 2weeks of anti-histamine and leukotriene antagonist therapy for symptom relief, both infants had no remnant skin le-sion or symptoms.
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KEYWORD
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Mastocytosis, Infant, Urticaria pigmentosa, Mastocytoma
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